ABSTRACT
BACKGROUND: The coronavirus disease 2019 pandemic (COVID-19) is the most important global health crisis to date. In this study, we performed an analysis to find the association between liver damage, FIB-4 score and the severity of COVID-19 disease. METHODS: We included a total of 580 patients that tested positive for SARS-CoV-2 infection and were hospitalized. No patient included had any known history of liver disease. Liver function tests were performed, and FIB-4 score was calculated in order to assess their involvement in the disease progression. RESULTS: More than half of the patients had elevated liver function tests. Age, high body mass index, associated heart disease and diabetes were associated with poor outcome. Corticosteroids, antibiotics, and anticoagulants strongly correlated with liver injuries. Liver impairment and injury, as well as a FIB-4 score higher than 3.5, also correlated with higher degrees of disease severity. CONCLUSION: Liver injury and elevated FIB-4 score were associated with poor clinical outcome and disease severity, as well as being a valuable tool to predict COVID-19-related mortality.
ABSTRACT
Even with the availability of HIV self-testing kits in some areas12, testing remains a major challenge in environments with limited access to these kits. [...]increased efforts are needed to increase access and facilitate testing. From the anamnesis, we found that the patient was hospitalized in June 2016 at NHS Hospital in UK, where she was diagnosed and with HIV C3 category infection, pulmonary and meningeal tuberculosis, diffuse non-Hodgkin's lymphoma (NHL) with large cells and was initiated on specific treatment but the patient cannot provide details about its nature, and she also underwent brain surgery to remove NHL-derived tumors. WBC = 6.8 ·10л3/шшл3, LYM = 1.67 ·10л3/шшл3, LYM = 24.4%, MON = 0.5·10Л3/шшЛ3, MON = 7.3%, NEU = 4.57·10Л3/шшЛ3, NEU = 66.9%, EOS = 0.06·10Л3/шшЛ3, EOS = 0.9%, BAS = 0.03 ·10Л3/шшЛ3, BAS = 0.5%, RBC = 3.79 ·10Л6/шшЛ3, HGB = 13.6 g/dl, HCT = 42.3%, MCV = 111 ;_